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Activated because of the antibiotic rifampicin and many plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Reaction to specific ligands is species-specific. Activated by Normally happening steroids, such as pregnenolone and progesterone. Binds to some response element in the promoters from the CYP3A4 and ABCB1/MDR1 gene

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